Version 5.4
Bos taurus Gene: CYBA
Summary
InnateDB Gene IDBG-630434.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYBA
Gene Name Cytochrome b-245 light chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003895
Encoded Proteins
IDBP-681887
Cytochrome b-245 light chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20142487
[Homo sapiens] CYBA is an NADPH oxidase and CYBA-dependent reactive oxygen species (ROS) are key regulators of neutrophil chemotactic migration.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051523:
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:13931107-13938075
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005080 ENSBTAP00000005080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0017124 SH3 domain binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006801 superoxide metabolic process
GO:0006954 inflammatory response
GO:0017004 cytochrome complex assembly
GO:0042554 superoxide anion generation
GO:0045087 innate immune response
GO:0045730 respiratory burst
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043020 NADPH oxidase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000051523
View Gene Order
ENSMUSG00000006519
View Gene Order
Pathways
NETPATH
REACTOME
REACT_220738
Phagosomal maturation (early endosomal stage) pathway
REACT_218962
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_213138
Immune System pathway
REACT_202485
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_214353
Signal Transduction pathway
REACT_226693
Signaling by VEGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_207087
Disease pathway
REACT_218645
Antigen processing-Cross presentation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_189085
Disease pathway
REACT_227951
Signaling by VEGF pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_230745
Immune System pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_199093
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa05140
Leishmaniasis pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt O46521
TrEMBL
UniProt Splice Variant
Entrez Gene 281111
UniGene Bt.4140
RefSeq NM_174034
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF036096 BC142380
GenPept AAC27246 AAI42381
RNA Seq Atlas 281111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca