Version 5.4
Bos taurus Protein: APRT
Summary
InnateDB Protein IDBP-682033.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APRT
Protein Name Adenine phosphoribosyltransferase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000841
InnateDB Gene IDBG-630572 (APRT)
Protein Structure
UniProt Annotation
Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002055 adenine binding
GO:0003999 adenine phosphoribosyltransferase activity
GO:0016208 AMP binding
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006168 adenine salvage
GO:0007625 grooming behavior
GO:0009116 nucleoside metabolic process
GO:0044209 AMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000836 Phosphoribosyltransferase domain
IPR005764 Adenine phosphoribosyl transferase
IPR029057 Phosphoribosyltransferase-like
PFAM PF00156
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q56JW4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 519017
UniGene
RefSeq NP_001020505
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY911367 BC102283
GenPept AAI02284 AAW82131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca