InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APRT

Summary

InnateDB Gene

IDBG-630572.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APRT

Gene Name

Adenine phosphoribosyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000639

Encoded Proteins

IDBP-682033

Adenine phosphoribosyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198931:
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:14057703-14060472

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000841

ENSBTAP00000000841

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002055	adenine binding
GO:0003999	adenine phosphoribosyltransferase activity
GO:0016208	AMP binding
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0006168	adenine salvage
GO:0007625	grooming behavior
GO:0009116	nucleoside metabolic process
GO:0044209	AMP salvage