InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRD

Summary

InnateDB Protein

IDBP-68219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRD

Protein Name

chordin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000204604

InnateDB Gene

IDBG-68217 (CHRD)

Protein Structure

UniProt Annotation

Function

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at the highest level in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0019955	cytokine binding
GO:0045545	syndecan binding

Biological Process

GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0009953	dorsal/ventral pattern formation
GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0033504	floor plate development
GO:0045668	negative regulation of osteoblast differentiation
GO:0045785	positive regulation of cell adhesion