Version 5.4
Bos taurus Protein: APOA4
Summary
InnateDB Protein IDBP-682268.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOA4
Protein Name apolipoprotein A-IV precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026345
InnateDB Gene IDBG-630787 (APOA4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0008289 lipid binding
GO:0016209 antioxidant activity
GO:0017127 cholesterol transporter activity
GO:0031210 phosphatidylcholine binding
GO:0042803 protein homodimerization activity
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006810 transport
GO:0006869 lipid transport
GO:0006982 response to lipid hydroperoxide
GO:0007159 leukocyte cell-cell adhesion
GO:0008203 cholesterol metabolic process
GO:0010873 positive regulation of cholesterol esterification
GO:0010898 positive regulation of triglyceride catabolic process
GO:0019430 removal of superoxide radicals
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032374 regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034445 negative regulation of plasma lipoprotein particle oxidation
GO:0035634 response to stilbenoid
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0042744 hydrogen peroxide catabolic process
GO:0043691 reverse cholesterol transport
GO:0044240 multicellular organismal lipid catabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0046470 phosphatidylcholine metabolic process
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0065005 protein-lipid complex assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000074 Apolipoprotein A1/A4/E
PFAM PF01442
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1N3Q7
UniProt Splice Variant
Entrez Gene 537301
UniGene Bt.15890
RefSeq NP_001032557
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040389 GJ062397
GenPept DAA22387

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca