InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NFYA

Summary

InnateDB Protein

IDBP-682282.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYA

Protein Name

Nuclear transcription factor Y subunit alpha

Synonyms

CBF-B; NF-YA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013080

InnateDB Gene

IDBG-630795 (NFYA)

Protein Structure

UniProt Annotation

Function

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00966}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000036	regulation of stem cell maintenance
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0016602	CCAAT-binding factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001289 CCAAT-binding transcription factor, subunit B

PFAM

PF02045

PRINTS

PR00616

PIRSF

SMART

SM00521

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9S2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539584

UniGene

Bt.91604

RefSeq

NP_001014956

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT020848

GenPept

AAX08865