Version 5.4
Bos taurus Gene: NFYA
Summary
InnateDB Gene IDBG-630795.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFYA
Gene Name Nuclear transcription factor Y subunit alpha
Synonyms CBF-B; NF-YA
Species Bos taurus
Ensembl Gene ENSBTAG00000009905
Encoded Proteins
IDBP-682279
Nuclear transcription factor Y subunit alpha
IDBP-682282
Nuclear transcription factor Y subunit alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001167:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:15006380-15030449
Strand Forward strand
Band
Transcripts
ENSBTAT00000047312 ENSBTAP00000044528
ENSBTAT00000013080 ENSBTAP00000013080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000036 regulation of stem cell maintenance
GO:2000648 positive regulation of stem cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000001167
View Gene Order
ENSMUSG00000023994
View Gene Order
Pathways
NETPATH
REACTOME
REACT_207291
PERK regulates gene expression pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_204438
ATF4 activates genes pathway
REACT_224406
ATF6-alpha activates chaperone genes pathway
REACT_213782
Metabolism of proteins pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_223232
Activation of gene expression by SREBF (SREBP) pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_208174
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_213463
ATF6-alpha activates chaperones pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18423
ATF6-alpha activates chaperone genes pathway
REACT_18348
ATF6-alpha activates chaperones pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
REACT_32838
ATF6-alpha activates chaperone genes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_243361
PERK regulates gene expression pathway
REACT_231897
ATF6-alpha activates chaperones pathway
REACT_198602
PPARA activates gene expression pathway
REACT_90370
ATF4 activates genes pathway
KEGG
hsa04612
Antigen processing and presentation pathway
mmu04612
Antigen processing and presentation pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt Q5E9S2
TrEMBL
UniProt Splice Variant
Entrez Gene 539584
UniGene Bt.84485 Bt.91604
RefSeq NM_001014956 XM_005223469 XM_005223470 XM_005223471 XM_005223472 XM_005223473 XM_005223474 XM_005223475 XM_005223476
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT020848
GenPept AAX08865
RNA Seq Atlas 539584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca