Version 5.4
Bos taurus Protein: BT.43673
Summary
InnateDB Protein IDBP-682286.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.43673
Protein Name cardiac phospholamban
Synonyms PLB;
Species Bos taurus
Ensembl Protein ENSBTAP00000017182
InnateDB Gene IDBG-630806 (BT.43673)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0042030 ATPase inhibitor activity
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0008016 regulation of heart contraction
GO:0010459 negative regulation of heart rate
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0045822 negative regulation of heart contraction
GO:0048738 cardiac muscle tissue development
GO:0051926 negative regulation of calcium ion transport
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086023 adrenergic receptor signaling pathway involved in heart process
GO:0086092 regulation of the force of heart contraction by cardiac conduction
GO:0090279 regulation of calcium ion import
GO:1901077 regulation of relaxation of muscle
GO:1901894 regulation of calcium-transporting ATPase activity
GO:1901895 negative regulation of calcium-transporting ATPase activity
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0090534 calcium ion-transporting ATPase complex
Protein Structure and Domains
PDB ID
InterPro IPR005984 Phospholamban
PFAM PF04272
PRINTS
PIRSF PIRSF001665
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F2Z4I4
UniProt Splice Variant
Entrez Gene 100125240
UniGene Bt.43673
RefSeq NP_001096789
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02025737 DAAA02025738
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca