InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.43673

Summary

InnateDB Gene

IDBG-630806.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.43673

Gene Name

cardiac phospholamban

Synonyms

PLB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012931

Encoded Proteins

IDBP-682286

cardiac phospholamban

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198523:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:32823612-32834377

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017182

ENSBTAP00000017182

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0042030	ATPase inhibitor activity

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0008016	regulation of heart contraction
GO:0010459	negative regulation of heart rate
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0045822	negative regulation of heart contraction
GO:0048738	cardiac muscle tissue development
GO:0051926	negative regulation of calcium ion transport
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086023	adrenergic receptor signaling pathway involved in heart process
GO:0086092	regulation of the force of heart contraction by cardiac conduction
GO:0090279	regulation of calcium ion import
GO:1901077	regulation of relaxation of muscle
GO:1901894	regulation of calcium-transporting ATPase activity
GO:1901895	negative regulation of calcium-transporting ATPase activity