Version 5.4
Bos taurus Protein: SOCS2
Summary
InnateDB Protein IDBP-682330.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS2
Protein Name Suppressor of cytokine signaling 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015929
InnateDB Gene IDBG-630845 (SOCS2)
Protein Structure
UniProt Annotation
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008269 JAK pathway signal transduction adaptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060396 growth hormone receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001496 SOCS protein, C-terminal
PFAM PF00017
PF14633
PF07525
PRINTS PR00401
PIRSF
SMART SM00252
SM00253
SM00969
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q861R0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338437
UniGene Bt.13273
RefSeq NP_803489
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY183451 AY183452 BC114662
GenPept AAI14663 AAO45009 AAO45010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca