InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SOCS2

Summary

InnateDB Gene

IDBG-630845.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS2

Gene Name

Suppressor of cytokine signaling 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012007

Encoded Proteins

IDBP-682330

Suppressor of cytokine signaling 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 14645718

[Homo sapiens] SOCS2 can enhance IL-2 and IL-3 signalling by accelerating SOCS3 degradation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120833:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:23523981-23528860

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015929

ENSBTAP00000015929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0032355	response to estradiol
GO:0032870	cellular response to hormone stimulus
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0046426	negative regulation of JAK-STAT cascade
GO:0060396	growth hormone receptor signaling pathway