Version 5.4
Bos taurus Protein: CCL2
Summary
InnateDB Protein IDBP-682439.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL2
Protein Name C-C motif chemokine 2
Synonyms MCP-1; MCP-1A; MCP1; MCP1A; SCYA2;
Species Bos taurus
Ensembl Protein ENSBTAP00000013146
InnateDB Gene IDBG-630954 (CCL2)
Protein Structure
UniProt Annotation
Function Chemotactic factor that attracts monocytes, but not neutrophils.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0031727 CCR2 chemokine receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0002548 monocyte chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0009617 response to bacterium
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035684 helper T cell extravasation
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043615 astrocyte cell migration
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0048246 macrophage chemotaxis
GO:0050870 positive regulation of T cell activation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:0090280 positive regulation of calcium ion import
GO:2000427 positive regulation of apoptotic cell clearance
GO:2000502 negative regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28291
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281043
UniGene Bt.2408
RefSeq NP_776431
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL EU276059 L32659 M84602
GenPept AAA30651 AAA60956 ABX72057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca