Version 5.4
Bos taurus Protein: PPIF
Summary
InnateDB Protein IDBP-682448.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIF
Protein Name peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor
Synonyms CyP-D; CypD;
Species Bos taurus
Ensembl Protein ENSBTAP00000022213
InnateDB Gene IDBG-630958 (PPIF)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0042277 peptide binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002931 response to ischemia
GO:0006457 protein folding
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 regulation of necrotic cell death
GO:0012501 programmed cell death
GO:0032780 negative regulation of ATPase activity
GO:0043066 negative regulation of apoptotic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0071243 cellular response to arsenic-containing substance
GO:0071277 cellular response to calcium ion
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090324 negative regulation of oxidative phosphorylation
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR029000 Cyclophilin-like domain
PFAM PF00160
PRINTS PR00153
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30404
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 414346
UniGene Bt.9791
RefSeq NP_001001597
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03123307 AY594335 EH176460
GenPept AAT02663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca