InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PPIF

Summary

InnateDB Gene

IDBG-630958.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIF

Gene Name

peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Synonyms

CyP-D; CypD

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016711

Encoded Proteins

IDBP-682448

peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108179:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:35167545-35173642

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022213

ENSBTAP00000022213

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0042277	peptide binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002931	response to ischemia
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0010849	regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939	regulation of necrotic cell death
GO:0012501	programmed cell death
GO:0032780	negative regulation of ATPase activity
GO:0043066	negative regulation of apoptotic process
GO:0046902	regulation of mitochondrial membrane permeability
GO:0070266	necroptotic process
GO:0070301	cellular response to hydrogen peroxide
GO:0071243	cellular response to arsenic-containing substance
GO:0071277	cellular response to calcium ion
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0090324	negative regulation of oxidative phosphorylation
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway