InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE1B

Summary

InnateDB Protein

IDBP-682569.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1B

Protein Name

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003552

InnateDB Gene

IDBG-631069 (PDE1B)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in central nervous system regions. Most abundant in basal ganglia. Also found in kidney papilla and adrenal medulla.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt