Version 5.4
Bos taurus Gene: PDE1B
Summary
InnateDB Gene IDBG-631069.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE1B
Gene Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004337
Encoded Proteins
IDBP-682565
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
IDBP-682569
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123360:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:25631976-25658534
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005680 ENSBTAP00000005680
ENSBTAT00000003552 ENSBTAP00000003552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0001975 response to amphetamine
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0008542 visual learning
GO:0030224 monocyte differentiation
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0042053 regulation of dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0046069 cGMP catabolic process
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000123360
View Gene Order
ENSMUSG00000022489
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_208036
Signaling by EGFR pathway
REACT_204121
PLCG1 events in ERBB2 signaling pathway
REACT_205369
Signaling by GPCR pathway
REACT_204365
Signaling by PDGF pathway
REACT_202422
Calmodulin induced events pathway
REACT_213902
DAG and IP3 signaling pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_216844
PLC-gamma1 signalling pathway
REACT_202837
Signaling by FGFR pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_204754
EGFR interacts with phospholipase C-gamma pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_212942
Cam-PDE 1 activation pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_211557
G-protein mediated events pathway
REACT_209440
Platelet homeostasis pathway
REACT_208097
Nitric oxide stimulates guanylate cyclase pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_214436
GPCR downstream signaling pathway
REACT_213422
PLC beta mediated events pathway
REACT_205403
cGMP effects pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_202198
Phospholipase C-mediated cascade pathway
REACT_212750
Downstream signal transduction pathway
REACT_219672
Opioid Signalling pathway
REACT_216714
Innate Immune System pathway
REACT_223374
Ca-dependent events pathway
REACT_216082
CaM pathway pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15408
Cam-PDE 1 activation pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_259326
Ca-dependent events pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_230745
Immune System pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_240702
CaM pathway pathway
REACT_242976
Signaling by EGFR pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_227001
Cam-PDE 1 activation pathway
REACT_248921
Signalling by NGF pathway
REACT_229620
cGMP effects pathway
REACT_263353
Signaling by PDGF pathway
REACT_245499
Nitric oxide stimulates guanylate cyclase pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242845
Opioid Signalling pathway
REACT_215587
Calmodulin induced events pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa00230
Purine metabolism pathway
hsa04020
Calcium signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.3910
RefSeq NM_174415 XM_005206092 XM_005206093 XM_005206094 XM_005206095 XM_005206096 XM_005206097 XM_005206098 XM_005206099 XM_005206100
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca