InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HTRA2

Summary

InnateDB Protein

IDBP-682774.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTRA2

Protein Name

Serine protease HTRA2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026804

InnateDB Gene

IDBG-631258 (HTRA2)

Protein Structure

UniProt Annotation

Function

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010942	positive regulation of cell death
GO:0030900	forebrain development
GO:0034605	cellular response to heat
GO:0040014	regulation of multicellular organism growth
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048666	neuron development
GO:0071363	cellular response to growth factor stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0035631	CD40 receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001478 PDZ domain
IPR001940 Peptidase S1C
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089
PF00595
PF13180

PRINTS

PR00834

PIRSF

SMART

SM00020
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JNK3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

523039

UniGene

Bt.61801

RefSeq

NP_001071424

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126737

GenPept

AAI26738