InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HTRA2

Summary

InnateDB Gene

IDBG-631258.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTRA2

Gene Name

Serine protease HTRA2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020124

Encoded Proteins

IDBP-682774

Serine protease HTRA2, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115317:
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:10089786-10093086

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026804

ENSBTAP00000026804

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010942	positive regulation of cell death
GO:0030900	forebrain development
GO:0034605	cellular response to heat
GO:0040014	regulation of multicellular organism growth
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048666	neuron development
GO:0071363	cellular response to growth factor stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0035631	CD40 receptor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000115317

View Gene Order

ENSMUSG00000068329

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05012

Parkinson's disease pathway

mmu05012

Parkinson's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.61801

RefSeq

NM_001077956

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas