Version 5.4
Bos taurus Protein: TARBP2
Summary
InnateDB Protein IDBP-682775.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARBP2
Protein Name RISC-loading complex subunit TARBP2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000558
InnateDB Gene IDBG-631247 (TARBP2)
Protein Structure
UniProt Annotation
Function Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03034}. Cytoplasm, perinuclear region {ECO:0000255HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255HAMAP-Rule:MF_03034}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006417 regulation of translation
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070 positive regulation of viral genome replication
GO:0046782 regulation of viral transcription
GO:0050689 negative regulation of defense response to virus by host
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016442 RISC complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR014720 Double-stranded RNA-binding domain
PFAM PF00035
PRINTS
PIRSF
SMART SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0IIG6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514674
UniGene Bt.4728
RefSeq NP_001069146
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122653 CK769751
GenPept AAI22654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca