InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TARBP2

Summary

InnateDB Gene

IDBG-631247.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TARBP2

Gene Name

RISC-loading complex subunit TARBP2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000435

Encoded Proteins

IDBP-682775

RISC-loading complex subunit TARBP2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139546:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:26681522-26686845

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000558

ENSBTAP00000000558

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0035197	siRNA binding
GO:0035198	miRNA binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006417	regulation of translation
GO:0030422	production of siRNA involved in RNA interference
GO:0030423	targeting of mRNA for destruction involved in RNA interference
GO:0031047	gene silencing by RNA
GO:0031054	pre-miRNA processing
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA
GO:0045070	positive regulation of viral genome replication
GO:0046782	regulation of viral transcription
GO:0050689	negative regulation of defense response to virus by host