Version 5.4
Bos taurus Protein: EXO1
Summary
InnateDB Protein IDBP-682938.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXO1
Protein Name exonuclease 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012365
InnateDB Gene IDBG-631406 (EXO1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' exodeoxyribonuclease activity
GO:0043566 structure-specific DNA binding
GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0048256 flap endonuclease activity
GO:0051908 double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0000738 DNA catabolic process, exonucleolytic
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0045190 isotype switching
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006085 XPG N-terminal
IPR006086 XPG-I domain
IPR008918 Helix-hairpin-helix motif, class 2
IPR020045 5\'-3\' exonuclease, C-terminal domain
IPR029060 PIN domain-like
PFAM PF00752
PF00867
PF01367
PF09293
PRINTS
PIRSF
SMART SM00485
SM00484
SM00279
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BF15
UniProt Splice Variant
Entrez Gene 506390
UniGene Bt.62135
RefSeq XP_002694001
HUGO HGNC:3511
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042804
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca