InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EXO1

Summary

InnateDB Gene

IDBG-631406.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXO1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009396

Encoded Proteins

IDBP-682938

exonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174371:
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a protein with 5\' to 3\' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:35747266-35788726

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012365

ENSBTAP00000012365

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0035312	5'-3' exodeoxyribonuclease activity
GO:0043566	structure-specific DNA binding
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0048256	flap endonuclease activity
GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0090305	nucleic acid phosphodiester bond hydrolysis