Version 5.4
Homo sapiens Protein: FUT4
Summary
InnateDB Protein IDBP-68301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUT4
Protein Name fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Synonyms CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX; SSEA-1;
Species Homo sapiens
Ensembl Protein ENSP00000351602
InnateDB Gene IDBG-68299 (FUT4)
Protein Structure
UniProt Annotation
Function May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Subcellular Localization Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0046920 alpha-(1->3)-fucosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0036065 fucosylation
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR001503 Glycosyl transferase, family 10
PFAM PF00852
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22083
PhosphoSite PhosphoSite-P22083
TrEMBL
UniProt Splice Variant
Entrez Gene 2526
UniGene Hs.390420
RefSeq NP_002024
HUGO HGNC:4015
OMIM 104230
CCDS CCDS8301
HPRD 00083
IMGT
EMBL AP000943 BC136373 BC136374 CH471065 M58596 M58597 M65030 S65161
GenPept AAA63172 AAA63173 AAA92977 AAB20349 AAI36374 AAI36375 EAW66938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca