InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NAPEPLD

Summary

InnateDB Protein

IDBP-683013.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAPEPLD

Protein Name

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Synonyms

NAPE-PLD;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018833

InnateDB Gene

IDBG-631475 (NAPEPLD)

Protein Structure

UniProt Annotation

Function

Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0006629	lipid metabolic process
GO:0009395	phospholipid catabolic process
GO:0016042	lipid catabolic process

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001279 Beta-lactamase-like

PFAM

PF00753

PRINTS

PIRSF

SMART

SM00849

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58CN9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

541291

UniGene

Bt.63822

RefSeq

NP_001015680

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021908

GenPept

AAX46755