Version 5.4
Bos taurus Protein: UNC119
Summary
InnateDB Protein IDBP-683233.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC119
Protein Name Protein unc-119 homolog A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017411
InnateDB Gene IDBG-631679 (UNC119)
Protein Structure
UniProt Annotation
Function Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=ocalizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006810 transport
GO:0007109 cytokinesis, completion of separation
GO:0007601 visual perception
GO:0015031 protein transport
GO:0042953 lipoprotein transport
GO:0050896 response to stimulus
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:1900186 negative regulation of clathrin-mediated endocytosis
GO:2001287 negative regulation of caveolin-mediated endocytosis
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0045171 intercellular bridge
GO:0051233 spindle midzone
Protein Structure and Domains
PDB ID
InterPro IPR008015 GMP phosphodiesterase, delta subunit
IPR014756 Immunoglobulin E-set
PFAM PF05351
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYR2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538501
UniGene Bt.48955
RefSeq NP_001029817
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103449
GenPept AAI03450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca