InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LAMTOR2

Summary

InnateDB Protein

IDBP-683260.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMTOR2

Protein Name

Ragulator complex protein LAMTOR2

Synonyms

MAPBPIP; ROBLD3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000045185

InnateDB Gene

IDBG-631707 (LAMTOR2)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0000186	activation of MAPKK activity
GO:0016049	cell growth
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0043547	positive regulation of GTPase activity
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005770	late endosome
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome
GO:0071986	Ragulator complex

Protein Structure and Domains

PDB ID

InterPro

IPR004942 Dynein light chain-related

PFAM

PF03259

PRINTS

PIRSF

SMART

SM00960

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T132

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

616375

UniGene

RefSeq

NP_001029963

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102146

GenPept

AAI02147