Version 5.4
Bos taurus Gene: LAMTOR2
Summary
InnateDB Gene IDBG-631707.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMTOR2
Gene Name Ragulator complex protein LAMTOR2
Synonyms MAPBPIP; ROBLD3
Species Bos taurus
Ensembl Gene ENSBTAG00000011754
Encoded Proteins
IDBP-683260
Ragulator complex protein LAMTOR2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116586:
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14763800-14766875
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048084 ENSBTAP00000045185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000186 activation of MAPKK activity
GO:0016049 cell growth
GO:0032008 positive regulation of TOR signaling
GO:0034613 cellular protein localization
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
GO:0071986 Ragulator complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116586
View Gene Order
ENSMUSG00000028062
View Gene Order
Cross-References
SwissProt Q3T132
TrEMBL
UniProt Splice Variant
Entrez Gene 616375
UniGene
RefSeq NM_001034791
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102146
GenPept AAI02147
RNA Seq Atlas 616375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca