Version 5.4
Bos taurus Protein: SNX3
Summary
InnateDB Protein IDBP-683321.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX3
Protein Name Sorting nexin-3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025026
InnateDB Gene IDBG-631765 (SNX3)
Protein Structure
UniProt Annotation
Function Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation (By similarity). {ECO:0000250}.
Subcellular Localization Early endosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0019903 protein phosphatase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0032268 regulation of cellular protein metabolic process
GO:0033157 regulation of intracellular protein transport
GO:0033572 transferrin transport
GO:0042541 hemoglobin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0010008 endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001683 Phox homologous domain
PFAM PF00787
PRINTS
PIRSF
SMART SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1RMH8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 528265
UniGene Bt.67315
RefSeq NP_001073246
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114888
GenPept AAI14889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca