InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: UCHL3

Summary

InnateDB Protein

IDBP-683465.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCHL3

Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035448

InnateDB Gene

IDBG-631884 (UCHL3)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0043130	ubiquitin binding

Biological Process

GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030163	protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase

PFAM

PF01088

PRINTS

PR00707

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2TBG8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

520170

UniGene

Bt.70102

RefSeq

NP_001035631

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC110247

GenPept

AAI10248