Version 5.4
Bos taurus Gene: UCHL3
Summary
InnateDB Gene IDBG-631884.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL3
Gene Name Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008024
Encoded Proteins
IDBP-683465
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118939:
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50948444-50997544
Strand Forward strand
Band
Transcripts
ENSBTAT00000035577 ENSBTAP00000035448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030163 protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000118939
View Gene Order
ENSMUSG00000022111
View Gene Order
Cross-References
SwissProt Q2TBG8
TrEMBL
UniProt Splice Variant
Entrez Gene 520170
UniGene Bt.27926 Bt.62266 Bt.70102
RefSeq NM_001040541 XM_005213843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110247
GenPept AAI10248
RNA Seq Atlas 520170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca