InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MARCH8

Summary

InnateDB Protein

IDBP-683582.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH8

Protein Name

E3 ubiquitin-protein ligase MARCH8

Synonyms

c-MIR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000039686

InnateDB Gene

IDBG-632000 (MARCH8)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042289	MHC class II protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002376	immune system process
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II
GO:0016567	protein ubiquitination
GO:0045347	negative regulation of MHC class II biosynthetic process

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF12906
PF00097

PRINTS

PIRSF

SMART

SM00184
SM00744

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VD59

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540667

UniGene

Bt.8182

RefSeq

NP_001069700

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC119819

GenPept

AAI19820