Version 5.4
Bos taurus Gene: MARCH8
Summary
InnateDB Gene IDBG-632000.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH8
Gene Name E3 ubiquitin-protein ligase MARCH8
Synonyms c-MIR
Species Bos taurus
Ensembl Gene ENSBTAG00000019537
Encoded Proteins
IDBP-683582
E3 ubiquitin-protein ligase MARCH8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165406:
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:44612704-44722610
Strand Forward strand
Band
Transcripts
ENSBTAT00000039901 ENSBTAP00000039686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042289 MHC class II protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002376 immune system process
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0016567 protein ubiquitination
GO:0045347 negative regulation of MHC class II biosynthetic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165406
View Gene Order
ENSMUSG00000025702
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.65928 Bt.8182
RefSeq NM_001076232 XM_005226591 XM_005226592 XM_005226593 XM_005226594 XM_005226595 XM_005226596 XM_005226597 XM_005226598 XM_005226599 XM_005226600 XM_005226601 XM_005226602 XM_005226606 XM_005226607
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca