InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SORL1

Summary

InnateDB Protein

IDBP-683801.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SORL1

Protein Name

sortilin-related receptor, L(DLR class) A repeats containing

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019457

InnateDB Gene

IDBG-632166 (SORL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding
GO:0030306	ADP-ribosylation factor binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006605	protein targeting
GO:0006622	protein targeting to lysosome
GO:0006892	post-Golgi vesicle-mediated transport
GO:0014910	regulation of smooth muscle cell migration
GO:0032091	negative regulation of protein binding
GO:0032460	negative regulation of protein oligomerization
GO:0043407	negative regulation of MAP kinase activity
GO:0045053	protein retention in Golgi apparatus
GO:0045732	positive regulation of protein catabolic process
GO:0050768	negative regulation of neurogenesis
GO:0051604	protein maturation
GO:0070863	positive regulation of protein exit from endoplasmic reticulum
GO:1901215	negative regulation of neuron death
GO:1902430	negative regulation of beta-amyloid formation
GO:1902771	positive regulation of choline O-acetyltransferase activity
GO:1902948	negative regulation of tau-protein kinase activity
GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955	positive regulation of early endosome to recycling endosome transport
GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966	positive regulation of protein localization to early endosome
GO:1902997	negative regulation of neurofibrillary tangle assembly
GO:2001137	positive regulation of endocytic recycling

Cellular Component

GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005768	endosome
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031985	Golgi cisterna
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR003961 Fibronectin, type III
IPR006581 VPS10

PFAM

PF00058
PF00008
PF00057
PF00041
PF01108

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00192
SM00060
SM00602

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt