Version 5.4
Bos taurus Gene: SORL1
Summary
InnateDB Gene IDBG-632166.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORL1
Gene Name sortilin-related receptor precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014611
Encoded Proteins
IDBP-683801
sortilin-related receptor, L(DLR class) A repeats containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137642:
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer\'s Disease.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:32584734-32755339
Strand Forward strand
Band
Transcripts
ENSBTAT00000019457 ENSBTAP00000019457
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
GO:0030306 ADP-ribosylation factor binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0006605 protein targeting
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0014910 regulation of smooth muscle cell migration
GO:0032091 negative regulation of protein binding
GO:0032460 negative regulation of protein oligomerization
GO:0043407 negative regulation of MAP kinase activity
GO:0045053 protein retention in Golgi apparatus
GO:0045732 positive regulation of protein catabolic process
GO:0050768 negative regulation of neurogenesis
GO:0051604 protein maturation
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:1901215 negative regulation of neuron death
GO:1902430 negative regulation of beta-amyloid formation
GO:1902771 positive regulation of choline O-acetyltransferase activity
GO:1902948 negative regulation of tau-protein kinase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 positive regulation of early endosome to recycling endosome transport
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031985 Golgi cisterna
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137642
View Gene Order
ENSMUSG00000049313
View Gene Order
Cross-References
SwissProt
TrEMBL E1BPZ1
UniProt Splice Variant
Entrez Gene 533166
UniGene Bt.17849
RefSeq NM_001192757
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040538 DAAA02040539 DAAA02040540 DAAA02040541
GenPept
RNA Seq Atlas 533166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca