Version 5.4
Bos taurus Protein: RASGRP3
Summary
InnateDB Protein IDBP-683895.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRP3
Protein Name ras guanyl-releasing protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000044100
InnateDB Gene IDBG-632283 (RASGRP3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0017016 Ras GTPase binding
GO:0019900 kinase binding
GO:0046582 Rap GTPase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor domain
PFAM PF00618
PF00617
PF00036
PF13202
PF13405
PF00130
PRINTS PR00008
PIRSF
SMART SM00229
SM00147
SM00054
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0VD52
UniProt Splice Variant
Entrez Gene 523745
UniGene Bt.61807
RefSeq NP_001069316
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119832 DAAA02030471
GenPept AAI19833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca