InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LOC407111

Summary

InnateDB Protein

IDBP-683909.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOC407111

Protein Name

Fas ligand

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043860

InnateDB Gene

IDBG-632305 (LOC407111)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525	negative regulation of angiogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046666	retinal cell programmed cell death
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006052 Tumour necrosis factor domain
IPR006053 Tumour necrosis factor
IPR008983 Tumour necrosis factor-like domain
IPR028326 Tumor necrosis factor ligand superfamily member 6

PFAM

PF00229

PRINTS

PR01234
PR01681

PIRSF

SMART

SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt