InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LOC407111

Summary

InnateDB Gene

IDBG-632305.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOC407111

Gene Name

tumor necrosis factor ligand superfamily member 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032808

Encoded Proteins

IDBP-683909

Fas ligand

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117560:
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:41027788-41036681

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046575

ENSBTAP00000043860

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525	negative regulation of angiogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046666	retinal cell programmed cell death
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome