Version 5.4
Bos taurus Protein: SHC1
Summary
InnateDB Protein IDBP-683978.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHC1
Protein Name SHC-transforming protein 1
Synonyms p66shc;
Species Bos taurus
Ensembl Protein ENSBTAP00000040041
InnateDB Gene IDBG-632371 (SHC1)
Protein Structure
UniProt Annotation
Function Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 210 interaction(s) predicted by orthology.
Predicted by orthology
Total 210 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain
PFAM PF00017
PF14633
PF00640
PF14719
PRINTS PR00401
PR00629
PIRSF
SMART SM00252
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0IIE2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507196
UniGene Bt.4279
RefSeq NP_001068773
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122688 DQ125497
GenPept AAI22689 AAZ38953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca