Version 5.4
| Bos taurus Gene: SHC1 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-632371.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | SHC1 | ||||||||||||||||
| Gene Name | SHC-transforming protein 1 | ||||||||||||||||
| Synonyms | p66shc | ||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000019838 | ||||||||||||||||
| Encoded Proteins |
SHC-transforming protein 1
SHC-transforming protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160691:
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 3:15671383-15681845 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 210 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
Signaling by EGFR pathway
SHC activation pathway
Signalling to ERKs pathway
Cell surface interactions at the vascular wall pathway
SHC-mediated cascade pathway
Signaling by GPCR pathway
Tie2 Signaling pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by FGFR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
SHC1 events in EGFR signaling pathway
Hemostasis pathway
Immune System pathway
Interleukin receptor SHC signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
IGF1R signaling cascade pathway
FCERI mediated Ca+2 mobilization pathway
SHC-related events pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
Signaling by Insulin receptor pathway
Signaling by EGFR in Cancer pathway
Signalling to RAS pathway
SHC1 events in ERBB4 signaling pathway
IRE1alpha activates chaperones pathway
Metabolism of proteins pathway
SHC-related events triggered by IGF1R pathway
Integrin alphaIIb beta3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
GPCR downstream signaling pathway
Downstream signaling of activated FGFR pathway
Signaling by constitutively active EGFR pathway
XBP1(S) activates chaperone genes pathway
Signalling by NGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
G-protein beta:gamma signalling pathway
Unfolded Protein Response (UPR) pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Innate Immune System pathway
FCERI mediated MAPK activation pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Signaling by Interleukins pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal attenuation pathway
Fc epsilon receptor (FCERI) signaling pathway
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| KEGG | |||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSH pathway
TSLP pathway
Prolactin pathway
Oncostatin_M pathway
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| REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
GPVI-mediated activation cascade pathway
Signalling to RAS pathway
Signal attenuation pathway
SHC1 events in EGFR signaling pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
SHC1 events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
SHC activation pathway
Signaling by Insulin receptor pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
XBP1(S) activates chaperone genes pathway
IRE1alpha activates chaperones pathway
Signaling by constitutively active EGFR pathway
SHC-related events pathway
Unfolded Protein Response (UPR) pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Metabolism of proteins pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IGF1R signaling cascade pathway
Disease pathway
Hemostasis pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
SHC activation pathway
Disease pathway
SHC-related events pathway
Hemostasis pathway
Signaling by constitutively active EGFR pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Unfolded Protein Response (UPR) pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
Signal attenuation pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Metabolism of proteins pathway
SHC-mediated signalling pathway
Downstream signaling of activated FGFR pathway
IRE1alpha activates chaperones pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Insulin receptor signalling cascade pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interleukin receptor SHC signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signalling by NGF pathway
Adaptive Immune System pathway
SHC-mediated cascade pathway
XBP1(S) activates chaperone genes pathway
NGF signalling via TRKA from the plasma membrane pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
Integrin alphaIIb beta3 signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR pathway
Platelet Aggregation (Plug Formation) pathway
FCERI mediated MAPK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
ErbB signaling pathway pathway
Glioma pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
ErbB signaling pathway pathway
Insulin signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Glioma pathway
Chronic myeloid leukemia pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
Integrin signaling pathway pathway
IL-5 signaling pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
Integrin signaling pathway pathway
IL-5 signaling pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
TCR signaling in naïve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
ErbB4 signaling events
TCR signaling in naïve CD4+ T cells
Internalization of ErbB1
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
a6b1 and a6b4 Integrin signaling
IGF1 pathway
EPO signaling pathway
EPHB forward signaling
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
FGF signaling pathway
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
TGF-beta receptor signaling
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
Insulin Pathway
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| Cross-References | |||||||||||||||||
| SwissProt | Q0IIE2 | ||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 507196 | ||||||||||||||||
| UniGene | Bt.4279 | ||||||||||||||||
| RefSeq | NM_001075305 NM_001164061 XM_005203672 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | BC122688 DQ125497 | ||||||||||||||||
| GenPept | AAI22689 AAZ38953 | ||||||||||||||||
| RNA Seq Atlas | 507196 | ||||||||||||||||