InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SHC1

Summary

InnateDB Protein

IDBP-683979.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHC1

Protein Name

SHC-transforming protein 1

Synonyms

p66shc;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026432

InnateDB Gene

IDBG-632371 (SHC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 210 interaction(s) predicted by orthology.

Predicted by orthology
Total	210 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain

PFAM

PF00017
PF14633
PF00640
PF14719

PRINTS

PR00401
PR00629

PIRSF

SMART

SM00252
SM00462

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1B716

UniProt Splice Variant

Entrez Gene

507196

UniGene

Bt.4279

RefSeq

NP_001157533

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC122688 DAAA02007156 DQ125497

GenPept

AAI22689 AAZ38953