InnateDB Protein
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IDBP-684058.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARL2BP
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Protein Name
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ADP-ribosylation factor-like protein 2-binding protein
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000006363
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InnateDB Gene
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IDBG-632446 (ARL2BP)
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Protein Structure
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Function |
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain. {ECO:0000269PubMed:10488091, ECO:0000269PubMed:11809823}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0042517
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positive regulation of tyrosine phosphorylation of Stat3 protein
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GO:0051457
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maintenance of protein location in nucleus
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GO:2001141
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regulation of RNA biosynthetic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR023379
ADP-ribosylation factor-like 2-binding protein, domain
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PFAM |
PF11527
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q32PC9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
613462
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UniGene |
Bt.11667
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RefSeq |
NP_001069742
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC108166
BC134728
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GenPept |
AAI08167
AAI34729
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