Version 5.4
Bos taurus Protein: ARL2BP
Summary
InnateDB Protein IDBP-684060.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL2BP
Protein Name ADP-ribosylation factor-like protein 2-binding protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000043580
InnateDB Gene IDBG-632446 (ARL2BP)
Protein Structure
UniProt Annotation
Function Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain. {ECO:0000269PubMed:10488091, ECO:0000269PubMed:11809823}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
Biological Process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0051457 maintenance of protein location in nucleus
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR023379 ADP-ribosylation factor-like 2-binding protein, domain
PFAM PF11527
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32PC9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613462
UniGene Bt.11667
RefSeq XP_005218765
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108166 BC134728
GenPept AAI08167 AAI34729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca