Version 5.4
Bos taurus Protein: AQP2
Summary
InnateDB Protein IDBP-684070.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP2
Protein Name Aquaporin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011024
InnateDB Gene IDBG-632459 (AQP2)
Protein Structure
UniProt Annotation
Function Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Localization Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Shuttles from vesicles to the apical membrane. Vasopressin- regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005372 water transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015250 water channel activity
Biological Process
GO:0003097 renal water transport
GO:0006810 transport
GO:0006833 water transport
GO:0015793 glycerol transport
GO:0042631 cellular response to water deprivation
GO:0071280 cellular response to copper ion
GO:0071288 cellular response to mercury ion
GO:0072205 metanephric collecting duct development
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
PFAM PF00230
PRINTS PR00783
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P79099
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539870
UniGene Bt.99512
RefSeq NP_001094669
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151512 Y10633
GenPept AAI51513 CAA71658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca