InnateDB Protein
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IDBP-684207.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NPPA
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Protein Name
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Natriuretic peptides AAtrial natriuretic factor
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000008819
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InnateDB Gene
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IDBG-632583 (NPPA)
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Protein Structure
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Function |
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000663
Natriuretic peptide
IPR002407
Natriuretic peptide, atrial type
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PFAM |
PF00212
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PRINTS |
PR00710
PR00711
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PIRSF |
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SMART |
SM00183
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TIGRFAMs |
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Modification |
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SwissProt |
P07501
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
281355
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UniGene |
Bt.29967
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RefSeq |
NP_776549
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC149029
M13145
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GenPept |
AAA30375
AAI49030
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