Version 5.4
Bos taurus Protein: ABR
Summary
InnateDB Protein IDBP-684211.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABR
Protein Name Active breakpoint cluster region-related protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011083
InnateDB Gene IDBG-632555 (ABR)
Protein Structure
UniProt Annotation
Function GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007420 brain development
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0032496 response to lipopolysaccharide
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042472 inner ear morphogenesis
GO:0043314 negative regulation of neutrophil degranulation
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
PFAM PF00168
PF00620
PF00621
PF00169
PRINTS PR00360
PIRSF
SMART SM00239
SM00324
SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QNS3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515556
UniGene Bt.43954
RefSeq NP_001039669
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114145 BC148971
GenPept AAI14146 AAI48972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca