InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABR

Summary

InnateDB Gene

IDBG-632555.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABR

Gene Name

Active breakpoint cluster region-related protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008424

Encoded Proteins

IDBP-684211

Active breakpoint cluster region-related protein

IDBP-684214

Active breakpoint cluster region-related protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159842:
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:22287405-22431563

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011083	ENSBTAP00000011083
ENSBTAT00000035191	ENSBTAP00000035069

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042472	inner ear morphogenesis
GO:0043314	negative regulation of neutrophil degranulation
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050885	neuromuscular process controlling balance