Bos taurus Protein: ABR
Summary
InnateDB Protein IDBP-684214.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABR
Protein Name Active breakpoint cluster region-related protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000035069
InnateDB Gene IDBG-632555 (ABR)
Protein Structure
UniProt Annotation
Function GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF00621
PRINTS
PIRSF
SMART SM00324
SM00325
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QNS3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515556
UniGene Bt.43954
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114145 BC148971
GenPept AAI14146 AAI48972