Version 5.4
Bos taurus Protein: GAP43
Summary
InnateDB Protein IDBP-684281.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAP43
Protein Name Neuromodulin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008460
InnateDB Gene IDBG-632650 (GAP43)
Protein Structure
UniProt Annotation
Function This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0010001 glial cell differentiation
GO:0016198 axon choice point recognition
GO:0030154 cell differentiation
GO:0040008 regulation of growth
GO:0045165 cell fate commitment
GO:0051489 regulation of filopodium assembly
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0031527 filopodium membrane
GO:0032584 growth cone membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR001422 Neuromodulin (GAP-43)
IPR017454 Neuromodulin (GAP-43), C-terminal
IPR018947 Neuromodulin gap junction N-terminal
PFAM PF00612
PF06614
PF10580
PRINTS PR00215
PIRSF
SMART SM00015
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06836
PhosphoSite PhosphoSite-P06836
TrEMBL
UniProt Splice Variant
Entrez Gene 281777
UniGene Bt.5457
RefSeq NP_976234
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY195838 BC118452
GenPept AAI18453 AAO60065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca