Version 5.4
Bos taurus Gene: GAP43
Summary
InnateDB Gene IDBG-632650.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAP43
Gene Name Neuromodulin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006451
Encoded Proteins
IDBP-684281
Neuromodulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172020:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has been termed a \'growth\' or \'plasticity\' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:60856308-60957246
Strand Forward strand
Band
Transcripts
ENSBTAT00000008460 ENSBTAP00000008460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0010001 glial cell differentiation
GO:0016198 axon choice point recognition
GO:0030154 cell differentiation
GO:0040008 regulation of growth
GO:0045165 cell fate commitment
GO:0051489 regulation of filopodium assembly
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0031527 filopodium membrane
GO:0032584 growth cone membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000172020
View Gene Order
ENSMUSG00000047261
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
KEGG
INOH
PID NCI
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt P06836
TrEMBL
UniProt Splice Variant
Entrez Gene 281777
UniGene Bt.5457
RefSeq NM_203358
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY195838 BC118452
GenPept AAI18453 AAO60065
RNA Seq Atlas 281777

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca