InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SRSF7

Summary

InnateDB Protein

IDBP-684284.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF7

Protein Name

Serine/arginine-rich splicing factor 7

Synonyms

SFRS7;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000033048

InnateDB Gene

IDBG-632653 (SRSF7)

Protein Structure

UniProt Annotation

Function

Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA- binding is semi-sequence specific (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0006810	transport
GO:0008380	RNA splicing
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR001878 Zinc finger, CCHC-type

PFAM

PF00076
PF00098

PRINTS

PIRSF

SMART

SM00360
SM00343

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T106

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507066

UniGene

RefSeq

NP_001029449

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102184

GenPept

AAI02185